Drug interactions
Diltiazem + Imipramine
Severity: Moderate
Diltiazem and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase imipramine concentrations, raising the risk of anticholinergic effects, sedation, orthostatic hypotension and cardiac conduction disturbances.
What this interaction means in plain words
Diltiazem and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Imipramine belongs to Central Nervous System.
Why it happens
Diltiazem inhibits CYP3A4-mediated demethylation of imipramine.
What to do
Monitor for tricyclic toxicity and consider an ECG; reduce the imipramine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Diltiazem with Imipramine?
MediHelp rates the interaction as moderate. Diltiazem and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase imipramine concentrations, raising the risk of anticholinergic effects, sedation, orthostatic hypotension and cardiac conduction disturbances.
How serious is the interaction between Diltiazem and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and consider an ECG; reduce the imipramine dose if adverse effects occur.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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