Drug interactions
Diltiazem + Lefamulin
Severity: Moderate
Diltiazem and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin is a CYP3A4 substrate, and diltiazem may increase its exposure, with a risk of QT prolongation and other adverse effects. Lefamulin also inhibits CYP3A4 and may increase diltiazem levels.
What this interaction means in plain words
Diltiazem and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Lefamulin belongs to Anti Bacterial.
Why it happens
Diltiazem inhibits CYP3A4 metabolism of lefamulin, with possible reciprocal inhibition.
What to do
Monitor for adverse effects including QT prolongation, especially with other QT-prolonging drugs, and monitor heart rate and blood pressure for diltiazem effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Diltiazem with Lefamulin?
MediHelp rates the interaction as moderate. Diltiazem and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin is a CYP3A4 substrate, and diltiazem may increase its exposure, with a risk of QT prolongation and other adverse effects. Lefamulin also inhibits CYP3A4 and may increase diltiazem levels.
How serious is the interaction between Diltiazem and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects including QT prolongation, especially with other QT-prolonging drugs, and monitor heart rate and blood pressure for diltiazem effects.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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