Drug interactions
Diltiazem + Mavacamten
Severity: Major
Diltiazem and Mavacamten: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce myocardial contractility, and diltiazem also inhibits mavacamten metabolism. This can precipitate systolic dysfunction and heart failure.
What this interaction means in plain words
Diltiazem and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diltiazem belongs to Cardiovascular; Mavacamten belongs to Cardiovascular.
Why it happens
Additive negative inotropy plus CYP3A4 inhibition by diltiazem raising mavacamten levels.
What to do
Avoid starting mavacamten in patients on diltiazem unless a specialist supervises. If used together, monitor LVEF and clinical status closely and adjust the mavacamten dose per echocardiography.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Diltiazem with Mavacamten?
MediHelp rates the interaction as major. Diltiazem and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs reduce myocardial contractility, and diltiazem also inhibits mavacamten metabolism. This can precipitate systolic dysfunction and heart failure.
How serious is the interaction between Diltiazem and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting mavacamten in patients on diltiazem unless a specialist supervises. If used together, monitor LVEF and clinical status closely and adjust the mavacamten dose per echocardiography.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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