Drug interactions
Diltiazem + Metformin-pioglitazone
Severity: Minor
Diltiazem and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is metabolised partly by CYP3A4 (and CYP2C8), and diltiazem is a moderate CYP3A4 inhibitor. Exposure to pioglitazone may increase slightly, but the effect is usually of limited clinical importance.
What this interaction means in plain words
Diltiazem and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated pioglitazone metabolism by diltiazem.
What to do
No routine adjustment is required; monitor for edema and hypoglycemia, and review pioglitazone dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Diltiazem and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is metabolised partly by CYP3A4 (and CYP2C8), and diltiazem is a moderate CYP3A4 inhibitor. Exposure to pioglitazone may increase slightly, but the effect is usually of limited clinical importance.
How serious is the interaction between Diltiazem and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor for edema and hypoglycemia, and review pioglitazone dose if adverse effects emerge.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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