Drug interactions
Diltiazem + Metformin-repaglinide
Severity: Moderate
Diltiazem and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem is a moderate CYP3A4 inhibitor and may raise repaglinide concentrations, increasing the risk of hypoglycemia. Calcium channel blockers can also slightly impair glucose tolerance, with a small effect on metformin response.
What this interaction means in plain words
Diltiazem and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 metabolism of repaglinide, with minor pharmacodynamic antagonism of glucose lowering.
What to do
Monitor blood glucose and hypoglycemia symptoms, and reduce the repaglinide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Diltiazem and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem is a moderate CYP3A4 inhibitor and may raise repaglinide concentrations, increasing the risk of hypoglycemia. Calcium channel blockers can also slightly impair glucose tolerance, with a small effect on metformin response.
How serious is the interaction between Diltiazem and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and hypoglycemia symptoms, and reduce the repaglinide dose if needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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