Drug interactions
Diltiazem + Palovarotene
Severity: Major
Diltiazem and Palovarotene: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem raises palovarotene exposure by inhibiting CYP3A4, which may increase retinoid toxicities such as mucocutaneous effects, and bone or growth effects.
What this interaction means in plain words
Diltiazem and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diltiazem belongs to Cardiovascular; Palovarotene belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 metabolism of palovarotene by diltiazem.
What to do
Avoid coadministration where possible; if unavoidable, reduce the palovarotene dose by half and monitor for retinoid adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Diltiazem with Palovarotene?
MediHelp rates the interaction as major. Diltiazem and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diltiazem raises palovarotene exposure by inhibiting CYP3A4, which may increase retinoid toxicities such as mucocutaneous effects, and bone or growth effects.
How serious is the interaction between Diltiazem and Palovarotene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible; if unavoidable, reduce the palovarotene dose by half and monitor for retinoid adverse effects.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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