Drug interactions
Aprepitant + Palovarotene
Severity: Major
Aprepitant and Palovarotene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may increase palovarotene exposure through CYP3A4 inhibition. This may increase retinoid toxicity such as mucocutaneous effects and premature epiphyseal closure risk in children.
What this interaction means in plain words
Aprepitant and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Palovarotene belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated palovarotene metabolism by aprepitant.
What to do
Avoid the combination if possible. If unavoidable, reduce the palovarotene dose by 50% and monitor for retinoid adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Carbamazepine + Palovarotene Major
Frequently asked questions
Can I take Aprepitant with Palovarotene?
MediHelp rates the interaction as major. Aprepitant and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant may increase palovarotene exposure through CYP3A4 inhibition. This may increase retinoid toxicity such as mucocutaneous effects and premature epiphyseal closure risk in children.
How serious is the interaction between Aprepitant and Palovarotene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If unavoidable, reduce the palovarotene dose by 50% and monitor for retinoid adverse effects.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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