Drug interactions
Diltiazem + Pioglitazone
Severity: Minor
Diltiazem and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem, a moderate CYP3A4 inhibitor, may modestly increase pioglitazone exposure. Clinical consequences are usually small but may include more fluid retention or hypoglycemia with other agents.
What this interaction means in plain words
Diltiazem and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Pioglitazone belongs to Endocrine.
Why it happens
Diltiazem inhibits CYP3A4, which contributes to pioglitazone metabolism alongside CYP2C8.
What to do
No routine dose change is needed; monitor glycemic control and edema when diltiazem is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Pioglitazone
Frequently asked questions
Can I take Diltiazem with Pioglitazone?
MediHelp rates the interaction as minor. Diltiazem and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diltiazem, a moderate CYP3A4 inhibitor, may modestly increase pioglitazone exposure. Clinical consequences are usually small but may include more fluid retention or hypoglycemia with other agents.
How serious is the interaction between Diltiazem and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor glycemic control and edema when diltiazem is started or stopped.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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