Drug interactions
Diltiazem + Repaglinide
Severity: Moderate
Diltiazem and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may modestly increase repaglinide levels, which can strengthen its glucose-lowering effect and cause hypoglycemia.
What this interaction means in plain words
Diltiazem and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Diltiazem inhibits CYP3A4, a contributor to repaglinide metabolism.
What to do
Monitor blood glucose and counsel on hypoglycemia symptoms; reduce the repaglinide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Diltiazem with Repaglinide?
MediHelp rates the interaction as moderate. Diltiazem and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may modestly increase repaglinide levels, which can strengthen its glucose-lowering effect and cause hypoglycemia.
How serious is the interaction between Diltiazem and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and counsel on hypoglycemia symptoms; reduce the repaglinide dose if glucose falls.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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