Drug interactions
Diltiazem + Suvorexant
Severity: Moderate
Diltiazem and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem increases suvorexant exposure, which can cause excessive next-day somnolence, impaired driving and other CNS effects.
What this interaction means in plain words
Diltiazem and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Suvorexant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of suvorexant by diltiazem.
What to do
Start suvorexant at the lower labeled dose of 5 mg at bedtime and titrate cautiously. Counsel patients about daytime drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Suvorexant
Frequently asked questions
Can I take Diltiazem with Suvorexant?
MediHelp rates the interaction as moderate. Diltiazem and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem increases suvorexant exposure, which can cause excessive next-day somnolence, impaired driving and other CNS effects.
How serious is the interaction between Diltiazem and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start suvorexant at the lower labeled dose of 5 mg at bedtime and titrate cautiously. Counsel patients about daytime drowsiness.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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