Drug interactions
Mifepristone + Suvorexant
Severity: Major
Mifepristone and Suvorexant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is metabolized mainly by CYP3A4, and strong inhibitors markedly raise its levels. This can cause excessive next-day sedation, impaired driving and somnolence.
What this interaction means in plain words
Mifepristone and Suvorexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Suvorexant belongs to Central Nervous System.
Why it happens
Mifepristone inhibits CYP3A4, decreasing suvorexant clearance.
What to do
Avoid co-use, as suvorexant is not recommended with strong CYP3A inhibitors; choose an alternative hypnotic and counsel about daytime impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Mifepristone with Suvorexant?
MediHelp rates the interaction as major. Mifepristone and Suvorexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Suvorexant is metabolized mainly by CYP3A4, and strong inhibitors markedly raise its levels. This can cause excessive next-day sedation, impaired driving and somnolence.
How serious is the interaction between Mifepristone and Suvorexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-use, as suvorexant is not recommended with strong CYP3A inhibitors; choose an alternative hypnotic and counsel about daytime impairment.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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