Drug interactions
Diltiazem + Triamcinolone
Severity: Moderate
Diltiazem and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem is a moderate CYP3A4 inhibitor and can raise triamcinolone exposure. This may increase systemic corticosteroid effects such as Cushingoid features, hyperglycemia and adrenal suppression, mainly with repeated or high doses.
What this interaction means in plain words
Diltiazem and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Triamcinolone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of triamcinolone by diltiazem.
What to do
Monitor for signs of corticosteroid excess during repeated or prolonged use. Consider reducing the triamcinolone dose or choosing an alternative if effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Triamcinolone?
MediHelp rates the interaction as moderate. Diltiazem and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem is a moderate CYP3A4 inhibitor and can raise triamcinolone exposure. This may increase systemic corticosteroid effects such as Cushingoid features, hyperglycemia and adrenal suppression, mainly with repeated or high doses.
How serious is the interaction between Diltiazem and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess during repeated or prolonged use. Consider reducing the triamcinolone dose or choosing an alternative if effects appear.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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