Drug interactions
Dimenhydrinate + Esketamine
Severity: Moderate
Dimenhydrinate and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate is a sedating antihistamine, and combined use with esketamine may increase drowsiness and psychomotor impairment.
What this interaction means in plain words
Dimenhydrinate and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression from esketamine and central H1 and muscarinic receptor blockade.
What to do
Monitor sedation after esketamine dosing. Counsel the patient to avoid driving after treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Esketamine?
MediHelp rates the interaction as moderate. Dimenhydrinate and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate is a sedating antihistamine, and combined use with esketamine may increase drowsiness and psychomotor impairment.
How serious is the interaction between Dimenhydrinate and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after esketamine dosing. Counsel the patient to avoid driving after treatment.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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