Drug interactions
Dimenhydrinate + Flurazepam
Severity: Moderate
Dimenhydrinate and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so together they can cause marked drowsiness and impaired coordination. Flurazepam's long-acting active metabolite can prolong the effect into the next day, raising the risk of falls and confusion in older adults.
What this interaction means in plain words
Dimenhydrinate and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A positive modulation plus central H1 antagonism.
What to do
Avoid the combination in older adults, or reduce the dose of one or both drugs. Counsel against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Flurazepam?
MediHelp rates the interaction as moderate. Dimenhydrinate and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so together they can cause marked drowsiness and impaired coordination. Flurazepam's long-acting active metabolite can prolong the effect into the next day, raising the risk of falls and confusion in older adults.
How serious is the interaction between Dimenhydrinate and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older adults, or reduce the dose of one or both drugs. Counsel against driving and alcohol use.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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