Drug interactions
Dimenhydrinate + Ketamine
Severity: Moderate
Dimenhydrinate and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate contains diphenhydramine and causes marked drowsiness. With ketamine, sedation and psychomotor impairment may be increased.
What this interaction means in plain words
Dimenhydrinate and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and NMDA antagonism.
What to do
Monitor sedation level and advise avoiding driving or activities requiring alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Ketamine?
MediHelp rates the interaction as moderate. Dimenhydrinate and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate contains diphenhydramine and causes marked drowsiness. With ketamine, sedation and psychomotor impairment may be increased.
How serious is the interaction between Dimenhydrinate and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and advise avoiding driving or activities requiring alertness.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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