Drug interactions
Dimenhydrinate + Levorphanol
Severity: Major
Dimenhydrinate and Levorphanol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and sedating antihistamines both depress the CNS. Combined use can cause profound sedation, respiratory depression and impaired psychomotor performance.
What this interaction means in plain words
Dimenhydrinate and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid the combination where possible, or use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Levorphanol?
MediHelp rates the interaction as major. Dimenhydrinate and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids and sedating antihistamines both depress the CNS. Combined use can cause profound sedation, respiratory depression and impaired psychomotor performance.
How serious is the interaction between Dimenhydrinate and Levorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients to avoid alcohol and driving.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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