Drug interactions
Dimenhydrinate + Metoclopramide intranasal
Severity: Moderate
Dimenhydrinate and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate is a sedating antihistamine with anticholinergic activity, while metoclopramide promotes gastric motility through dopamine antagonism and cholinergic stimulation. The anticholinergic effect can oppose the prokinetic action, and both drugs may add to drowsiness and, occasionally, extrapyramidal or CNS effects.
What this interaction means in plain words
Dimenhydrinate and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism of metoclopramide's cholinergic prokinetic effect by anticholinergic dimenhydrinate, plus additive CNS depression.
What to do
Avoid routine co-prescribing for the same indication; if both are required, monitor for reduced antiemetic or prokinetic benefit, sedation and movement disorders.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Dimenhydrinate and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate is a sedating antihistamine with anticholinergic activity, while metoclopramide promotes gastric motility through dopamine antagonism and cholinergic stimulation. The anticholinergic effect can oppose the prokinetic action, and both drugs may add to drowsiness and, occasionally, extrapyramidal or CNS effects.
How serious is the interaction between Dimenhydrinate and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-prescribing for the same indication; if both are required, monitor for reduced antiemetic or prokinetic benefit, sedation and movement disorders.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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