Drug interactions
Dimenhydrinate + Midazolam intranasal
Severity: Major
Dimenhydrinate and Midazolam intranasal: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a benzodiazepine that depresses respiration and consciousness, and dimenhydrinate adds sedative effects. Together they may deepen or prolong sedation and increase the risk of hypoventilation, airway obstruction and oxygen desaturation.
What this interaction means in plain words
Dimenhydrinate and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from GABA-A potentiation by midazolam and central H1 antagonism by dimenhydrinate.
What to do
Avoid giving dimenhydrinate around the time of intranasal midazolam where possible; if needed, monitor respiratory rate, oxygen saturation and level of consciousness closely. Ensure a caregiver or clinician is present who can manage the airway.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Midazolam intranasal?
MediHelp rates the interaction as major. Dimenhydrinate and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midazolam is a benzodiazepine that depresses respiration and consciousness, and dimenhydrinate adds sedative effects. Together they may deepen or prolong sedation and increase the risk of hypoventilation, airway obstruction and oxygen desaturation.
How serious is the interaction between Dimenhydrinate and Midazolam intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving dimenhydrinate around the time of intranasal midazolam where possible; if needed, monitor respiratory rate, oxygen saturation and level of consciousness closely. Ensure a caregiver or clinician is present who can manage the airway.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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