Drug interactions
Dimenhydrinate + Papaveretum
Severity: Moderate
Dimenhydrinate and Papaveretum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine, and combining it with a sedating antihistamine adds to drowsiness and respiratory depression. The risk is greatest in older, debilitated or opioid-naive patients.
What this interaction means in plain words
Dimenhydrinate and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1 antagonism.
What to do
Start with reduced doses and titrate carefully. Monitor sedation level and respiratory rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Papaveretum?
MediHelp rates the interaction as moderate. Dimenhydrinate and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum contains opium alkaloids including morphine, and combining it with a sedating antihistamine adds to drowsiness and respiratory depression. The risk is greatest in older, debilitated or opioid-naive patients.
How serious is the interaction between Dimenhydrinate and Papaveretum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses and titrate carefully. Monitor sedation level and respiratory rate.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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