Drug interactions
Dimenhydrinate + Pimozide
Severity: Moderate
Dimenhydrinate and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate contains diphenhydramine, a sedating antihistamine with anticholinergic activity. With pimozide, additive sedation and anticholinergic effects can occur.
What this interaction means in plain words
Dimenhydrinate and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for drowsiness and anticholinergic effects and advise against driving until the response is known. Use the lowest effective dose or an alternative antiemetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Pimozide?
MediHelp rates the interaction as moderate. Dimenhydrinate and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate contains diphenhydramine, a sedating antihistamine with anticholinergic activity. With pimozide, additive sedation and anticholinergic effects can occur.
How serious is the interaction between Dimenhydrinate and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and anticholinergic effects and advise against driving until the response is known. Use the lowest effective dose or an alternative antiemetic.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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