Drug interactions
Dimenhydrinate + Quazepam
Severity: Moderate
Dimenhydrinate and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic, and with dimenhydrinate it increases sedation, psychomotor impairment and next-day drowsiness. Falls and confusion are a particular concern in older adults.
What this interaction means in plain words
Dimenhydrinate and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and H1 antagonism.
What to do
Avoid combining in older patients where possible and use the lowest quazepam dose. Counsel on driving and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Quazepam?
MediHelp rates the interaction as moderate. Dimenhydrinate and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a long-acting benzodiazepine hypnotic, and with dimenhydrinate it increases sedation, psychomotor impairment and next-day drowsiness. Falls and confusion are a particular concern in older adults.
How serious is the interaction between Dimenhydrinate and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining in older patients where possible and use the lowest quazepam dose. Counsel on driving and alcohol avoidance.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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