Drug interactions
Dimenhydrinate + Triazolam
Severity: Moderate
Dimenhydrinate and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam and dimenhydrinate together intensify sedation and impair psychomotor performance and memory. Older adults face a higher risk of falls and confusion.
What this interaction means in plain words
Dimenhydrinate and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and H1 antagonism.
What to do
Use the lowest triazolam dose and avoid the combination in older patients where possible. Counsel on driving and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Triazolam?
MediHelp rates the interaction as moderate. Dimenhydrinate and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam and dimenhydrinate together intensify sedation and impair psychomotor performance and memory. Older adults face a higher risk of falls and confusion.
How serious is the interaction between Dimenhydrinate and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest triazolam dose and avoid the combination in older patients where possible. Counsel on driving and alcohol avoidance.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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