Drug interactions
Diphenhydramine + Hyaluronidase
Severity: Minor
Diphenhydramine and Hyaluronidase: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labeling notes that large systemic doses of antihistamines may make tissues partially resistant to hyaluronidase. This may reduce the dispersing effect, so larger amounts of hyaluronidase may be required.
What this interaction means in plain words
Diphenhydramine and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diphenhydramine belongs to Respiratory; Hyaluronidase belongs to Miscellaneous.
Why it happens
Antihistamines may reduce tissue responsiveness to hyaluronidase; the exact mechanism is not established.
What to do
Assess the dispersal effect and increase the hyaluronidase dose if the response is inadequate. No action is needed with usual antihistamine doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenhydramine
Other interactions of Hyaluronidase
Frequently asked questions
Can I take Diphenhydramine with Hyaluronidase?
MediHelp rates the interaction as minor. Diphenhydramine and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labeling notes that large systemic doses of antihistamines may make tissues partially resistant to hyaluronidase. This may reduce the dispersing effect, so larger amounts of hyaluronidase may be required.
How serious is the interaction between Diphenhydramine and Hyaluronidase?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess the dispersal effect and increase the hyaluronidase dose if the response is inadequate. No action is needed with usual antihistamine doses.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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