Drug interactions
Hyaluronidase + Lidocaine
Severity: Moderate
Hyaluronidase and Lidocaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyaluronidase breaks down tissue hyaluronan and spreads injected lidocaine over a wider area. This speeds onset of anesthesia but shortens its duration and raises systemic uptake, increasing the chance of systemic toxicity with large doses.
What this interaction means in plain words
Hyaluronidase and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hyaluronidase belongs to Miscellaneous; Lidocaine belongs to Cardiovascular.
Why it happens
Hyaluronidase depolymerizes interstitial hyaluronic acid, increasing local diffusion and vascular absorption of lidocaine.
What to do
Keep the total lidocaine dose within the maximum recommended limit and consider that repeat dosing may be needed because the block is shorter. Monitor for early signs of systemic toxicity such as perioral numbness, tinnitus and lightheadedness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Hyaluronidase
Frequently asked questions
Can I take Hyaluronidase with Lidocaine?
MediHelp rates the interaction as moderate. Hyaluronidase and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyaluronidase breaks down tissue hyaluronan and spreads injected lidocaine over a wider area. This speeds onset of anesthesia but shortens its duration and raises systemic uptake, increasing the chance of systemic toxicity with large doses.
How serious is the interaction between Hyaluronidase and Lidocaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the total lidocaine dose within the maximum recommended limit and consider that repeat dosing may be needed because the block is shorter. Monitor for early signs of systemic toxicity such as perioral numbness, tinnitus and lightheadedness.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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