Drug interactions
Diphenhydramine + Zuranolone
Severity: Moderate
Diphenhydramine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and impaired driving ability, and diphenhydramine adds sedative effects. Together they can increase psychomotor impairment and daytime drowsiness.
What this interaction means in plain words
Diphenhydramine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenhydramine belongs to Respiratory; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A positive modulation (zuranolone) and sedating H1 antagonism (diphenhydramine).
What to do
Avoid routine use of sedating antihistamines with zuranolone; if needed, reduce the dose of one agent and counsel the patient not to drive or operate machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diphenhydramine and Zuranolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diphenhydramine
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Diphenhydramine with Zuranolone?
MediHelp rates the interaction as moderate. Diphenhydramine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and impaired driving ability, and diphenhydramine adds sedative effects. Together they can increase psychomotor impairment and daytime drowsiness.
How serious is the interaction between Diphenhydramine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine use of sedating antihistamines with zuranolone; if needed, reduce the dose of one agent and counsel the patient not to drive or operate machinery.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
