Drug interactions
Diphenoxylate + Pimozide
Severity: Moderate
Diphenoxylate and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid antidiarrheal, and combined use with pimozide may cause additive sedation, particularly at higher doses.
What this interaction means in plain words
Diphenoxylate and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate belongs to Gastrointestinal Tract; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Keep to the labelled dose and monitor for drowsiness. Advise against alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Diphenoxylate with Pimozide?
MediHelp rates the interaction as moderate. Diphenoxylate and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid antidiarrheal, and combined use with pimozide may cause additive sedation, particularly at higher doses.
How serious is the interaction between Diphenoxylate and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep to the labelled dose and monitor for drowsiness. Advise against alcohol and driving until the response is known.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
Full monographs, dosing and an interaction checker in the MediHelp app
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