Drug interactions
Diphenoxylate + Tranylcypromine
Severity: Major
Diphenoxylate and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate labeling warns that MAO inhibitors may precipitate hypertensive crisis when combined with it. Additive CNS depression and anticholinergic effects may also occur.
What this interaction means in plain words
Diphenoxylate and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diphenoxylate belongs to Gastrointestinal Tract; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition may potentiate the pressor and CNS effects of this opioid-related antidiarrheal; the exact mechanism is not established.
What to do
Avoid use during tranylcypromine therapy and for 14 days after stopping it; use an alternative such as loperamide if appropriate. If given, monitor blood pressure and sedation closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Diphenoxylate with Tranylcypromine?
MediHelp rates the interaction as major. Diphenoxylate and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diphenoxylate labeling warns that MAO inhibitors may precipitate hypertensive crisis when combined with it. Additive CNS depression and anticholinergic effects may also occur.
How serious is the interaction between Diphenoxylate and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use during tranylcypromine therapy and for 14 days after stopping it; use an alternative such as loperamide if appropriate. If given, monitor blood pressure and sedation closely.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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