Drug interactions
Diphenoxylate-atropine + Echothiophate iodide
Severity: Minor
Diphenoxylate-atropine and Echothiophate iodide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Echothiophate is an ophthalmic irreversible cholinesterase inhibitor, and atropine is an antimuscarinic that opposes cholinergic stimulation. Systemic absorption from eye drops is small, and atropine may partly counter echothiophate's effects.
What this interaction means in plain words
Diphenoxylate-atropine and Echothiophate iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and an antimuscarinic.
What to do
No routine action is needed. Watch for reduced miotic effect or unexpected cholinergic or anticholinergic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diphenoxylate-atropine and Echothiophate iodide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Echothiophate iodide?
MediHelp rates the interaction as minor. Diphenoxylate-atropine and Echothiophate iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Echothiophate is an ophthalmic irreversible cholinesterase inhibitor, and atropine is an antimuscarinic that opposes cholinergic stimulation. Systemic absorption from eye drops is small, and atropine may partly counter echothiophate's effects.
How serious is the interaction between Diphenoxylate-atropine and Echothiophate iodide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Watch for reduced miotic effect or unexpected cholinergic or anticholinergic symptoms.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
