Drug interactions
Diphenoxylate-atropine + Glucagon intranasal
Severity: Moderate
Diphenoxylate-atropine and Glucagon intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon inhibits gastrointestinal motility, and anticholinergics such as atropine add to this effect. The combination can increase gastrointestinal adverse reactions such as ileus.
What this interaction means in plain words
Diphenoxylate-atropine and Glucagon intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of gastrointestinal motility.
What to do
For acute hypoglycemia, give glucagon without delay, since that need outweighs the concern. Monitor for abdominal distension or reduced bowel sounds afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Glucagon intranasal?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Glucagon intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucagon inhibits gastrointestinal motility, and anticholinergics such as atropine add to this effect. The combination can increase gastrointestinal adverse reactions such as ileus.
How serious is the interaction between Diphenoxylate-atropine and Glucagon intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For acute hypoglycemia, give glucagon without delay, since that need outweighs the concern. Monitor for abdominal distension or reduced bowel sounds afterward.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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