Drug interactions
Diphenoxylate-atropine + Lofepramine
Severity: Moderate
Diphenoxylate-atropine and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with antimuscarinic and sedative effects. Combined with diphenoxylate-atropine, it can increase anticholinergic effects such as constipation, urinary retention and dry mouth, as well as sedation.
What this interaction means in plain words
Diphenoxylate-atropine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects and additive CNS depression.
What to do
Monitor for urinary retention, constipation or ileus and excessive sedation, especially in older adults. Reduce doses or choose an alternative antidiarrheal if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Lofepramine?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with antimuscarinic and sedative effects. Combined with diphenoxylate-atropine, it can increase anticholinergic effects such as constipation, urinary retention and dry mouth, as well as sedation.
How serious is the interaction between Diphenoxylate-atropine and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation or ileus and excessive sedation, especially in older adults. Reduce doses or choose an alternative antidiarrheal if symptoms develop.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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