Drug interactions
Diphenoxylate-atropine + Marijuana
Severity: Moderate
Diphenoxylate-atropine and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can cause sedation, dizziness and impaired psychomotor performance, which may add to the CNS depressant effect of diphenoxylate. Cannabis may also cause tachycardia, which could add to the effect of atropine.
What this interaction means in plain words
Diphenoxylate-atropine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive tachycardia from cannabinoid and antimuscarinic effects.
What to do
Counsel patients about increased drowsiness and avoid driving or hazardous tasks. Monitor for excessive sedation and tachycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Marijuana?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can cause sedation, dizziness and impaired psychomotor performance, which may add to the CNS depressant effect of diphenoxylate. Cannabis may also cause tachycardia, which could add to the effect of atropine.
How serious is the interaction between Diphenoxylate-atropine and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about increased drowsiness and avoid driving or hazardous tasks. Monitor for excessive sedation and tachycardia.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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