Drug interactions
Diphenoxylate-atropine + Metoclopramide intranasal
Severity: Moderate
Diphenoxylate-atropine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide stimulates gut motility, whereas diphenoxylate and atropine slow it, so they have opposing effects and reduce each other's benefit. Both can also cause CNS effects such as drowsiness.
What this interaction means in plain words
Diphenoxylate-atropine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism of gastrointestinal motility.
What to do
Avoid concurrent use unless both are clearly needed. If used together, monitor for loss of effect from either drug and for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide stimulates gut motility, whereas diphenoxylate and atropine slow it, so they have opposing effects and reduce each other's benefit. Both can also cause CNS effects such as drowsiness.
How serious is the interaction between Diphenoxylate-atropine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless both are clearly needed. If used together, monitor for loss of effect from either drug and for sedation.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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