Drug interactions
Diphenoxylate-atropine + Olanzapine
Severity: Moderate
Diphenoxylate-atropine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has anticholinergic and sedative activity that adds to the atropine and opioid effects of diphenoxylate-atropine. Excess drowsiness, constipation, urinary retention, tachycardia and confusion may result, and in severe cases reduced gut motility may progress to ileus.
What this interaction means in plain words
Diphenoxylate-atropine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Olanzapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects and additive CNS depression.
What to do
Monitor for sedation, constipation, urinary retention and signs of ileus, and use the shortest course of the antidiarrheal. Counsel patients about driving and other hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Diphenoxylate-atropine with Olanzapine?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has anticholinergic and sedative activity that adds to the atropine and opioid effects of diphenoxylate-atropine. Excess drowsiness, constipation, urinary retention, tachycardia and confusion may result, and in severe cases reduced gut motility may progress to ileus.
How serious is the interaction between Diphenoxylate-atropine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, constipation, urinary retention and signs of ileus, and use the shortest course of the antidiarrheal. Counsel patients about driving and other hazardous tasks.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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