Drug interactions
Diphenoxylate-atropine + Olopatadine intranasal
Severity: Moderate
Diphenoxylate-atropine and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olopatadine nasal spray can cause somnolence, and diphenoxylate has sedative effects, especially in overdose or in children. Combined use may increase drowsiness and psychomotor impairment.
What this interaction means in plain words
Diphenoxylate-atropine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Counsel patients about drowsiness and avoiding driving until the response is known. Consider an alternative to one agent if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olopatadine nasal spray can cause somnolence, and diphenoxylate has sedative effects, especially in overdose or in children. Combined use may increase drowsiness and psychomotor impairment.
How serious is the interaction between Diphenoxylate-atropine and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and avoiding driving until the response is known. Consider an alternative to one agent if sedation is excessive.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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