Drug interactions
Diphenoxylate-atropine + Pimozide
Severity: Moderate
Diphenoxylate-atropine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide has sedative and anticholinergic properties that add to the opioid and atropine effects of diphenoxylate-atropine. Excess drowsiness, constipation, and urinary retention may occur. Atropine-induced tachycardia may also be unwelcome given the QT risk of pimozide.
What this interaction means in plain words
Diphenoxylate-atropine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor for sedation and anticholinergic effects and use the antidiarrheal at the lowest effective dose. Check heart rate and ECG as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Diphenoxylate-atropine with Pimozide?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide has sedative and anticholinergic properties that add to the opioid and atropine effects of diphenoxylate-atropine. Excess drowsiness, constipation, and urinary retention may occur. Atropine-induced tachycardia may also be unwelcome given the QT risk of pimozide.
How serious is the interaction between Diphenoxylate-atropine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects and use the antidiarrheal at the lowest effective dose. Check heart rate and ECG as clinically indicated.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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