Drug interactions
Diphenoxylate-atropine + Promazine
Severity: Moderate
Diphenoxylate-atropine and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine has significant anticholinergic and sedating properties, which add to those of atropine. This may lead to dry mouth, constipation, urinary retention, confusion and tachycardia, especially in older adults.
What this interaction means in plain words
Diphenoxylate-atropine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic and CNS depressant effects.
What to do
Monitor for anticholinergic toxicity, including ileus and urinary retention, and avoid prolonged combined use in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Promazine?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine has significant anticholinergic and sedating properties, which add to those of atropine. This may lead to dry mouth, constipation, urinary retention, confusion and tachycardia, especially in older adults.
How serious is the interaction between Diphenoxylate-atropine and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, including ileus and urinary retention, and avoid prolonged combined use in older patients.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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