Drug interactions
Diphenoxylate-atropine + Thiothixene
Severity: Moderate
Diphenoxylate-atropine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is a sedating antipsychotic with anticholinergic activity, so with diphenoxylate-atropine it may increase drowsiness and anticholinergic effects such as constipation, urinary retention and confusion. Atropine may also slightly reduce oral absorption of thiothixene.
What this interaction means in plain words
Diphenoxylate-atropine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antimuscarinic effects, with possible reduced gut absorption of oral antipsychotic.
What to do
Monitor for oversedation and anticholinergic toxicity, especially in older patients, and reduce doses if needed. Check psychiatric response if the antipsychotic effect seems diminished.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Thiothixene?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is a sedating antipsychotic with anticholinergic activity, so with diphenoxylate-atropine it may increase drowsiness and anticholinergic effects such as constipation, urinary retention and confusion. Atropine may also slightly reduce oral absorption of thiothixene.
How serious is the interaction between Diphenoxylate-atropine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, especially in older patients, and reduce doses if needed. Check psychiatric response if the antipsychotic effect seems diminished.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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