Drug interactions
Diphenoxylate-atropine + Triazolam
Severity: Moderate
Diphenoxylate-atropine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid and triazolam is a potent benzodiazepine hypnotic, so taking them together can deepen sedation and impair psychomotor performance. Opioid and benzodiazepine combinations also carry a risk of respiratory depression, particularly in older or frail patients.
What this interaction means in plain words
Diphenoxylate-atropine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from opioid receptor agonism and GABA-A receptor potentiation.
What to do
Use the lowest effective doses for the shortest time and warn patients about drowsiness and driving. Monitor for excessive sedation and slowed breathing, especially in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Triazolam?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid and triazolam is a potent benzodiazepine hypnotic, so taking them together can deepen sedation and impair psychomotor performance. Opioid and benzodiazepine combinations also carry a risk of respiratory depression, particularly in older or frail patients.
How serious is the interaction between Diphenoxylate-atropine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and warn patients about drowsiness and driving. Monitor for excessive sedation and slowed breathing, especially in elderly patients.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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