Drug interactions
Diphenoxylate-atropine + Triclofos
Severity: Moderate
Diphenoxylate-atropine and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic that is converted to trichloroethanol, and combining it with the opioid diphenoxylate may increase drowsiness and reduce alertness. Excess sedation or respiratory depression is possible, mainly at higher doses or in vulnerable patients.
What this interaction means in plain words
Diphenoxylate-atropine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from the opioid effect of diphenoxylate and the GABA-ergic sedative effect of trichloroethanol.
What to do
Start triclofos at the lowest dose and monitor sedation and respiratory rate. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Triclofos?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic that is converted to trichloroethanol, and combining it with the opioid diphenoxylate may increase drowsiness and reduce alertness. Excess sedation or respiratory depression is possible, mainly at higher doses or in vulnerable patients.
How serious is the interaction between Diphenoxylate-atropine and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start triclofos at the lowest dose and monitor sedation and respiratory rate. Advise patients to avoid driving and alcohol.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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