Drug interactions
Diphenoxylate-atropine + Trospium chloride
Severity: Moderate
Diphenoxylate-atropine and Trospium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atropine in this product and trospium are both antimuscarinic drugs, so together they can cause additive anticholinergic effects such as dry mouth, constipation, urinary retention, tachycardia and blurred vision. Together with the antimotility action of diphenoxylate, there is a greater risk of severe constipation or ileus.
What this interaction means in plain words
Diphenoxylate-atropine and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blockade of muscarinic receptors.
What to do
Monitor for anticholinergic effects and bowel and bladder function, particularly in older patients. Reduce the dose or stop one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Trospium chloride?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atropine in this product and trospium are both antimuscarinic drugs, so together they can cause additive anticholinergic effects such as dry mouth, constipation, urinary retention, tachycardia and blurred vision. Together with the antimotility action of diphenoxylate, there is a greater risk of severe constipation or ileus.
How serious is the interaction between Diphenoxylate-atropine and Trospium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and bowel and bladder function, particularly in older patients. Reduce the dose or stop one agent if symptoms occur.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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