Drug interactions
Diphenoxylate-atropine + Umeclidinium bromide
Severity: Minor
Diphenoxylate-atropine and Umeclidinium bromide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is an inhaled long-acting antimuscarinic, and atropine is systemically anticholinergic. Combining them may add to systemic anticholinergic effects such as dry mouth, constipation, urinary retention and increased heart rate, although inhaled systemic exposure is low.
What this interaction means in plain words
Diphenoxylate-atropine and Umeclidinium bromide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Monitor for anticholinergic symptoms, especially in older patients or those with glaucoma or urinary obstruction. Review the need for diphenoxylate-atropine if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Umeclidinium bromide?
MediHelp rates the interaction as minor. Diphenoxylate-atropine and Umeclidinium bromide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Umeclidinium is an inhaled long-acting antimuscarinic, and atropine is systemically anticholinergic. Combining them may add to systemic anticholinergic effects such as dry mouth, constipation, urinary retention and increased heart rate, although inhaled systemic exposure is low.
How serious is the interaction between Diphenoxylate-atropine and Umeclidinium bromide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, especially in older patients or those with glaucoma or urinary obstruction. Review the need for diphenoxylate-atropine if symptoms develop.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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