Drug interactions
Diphenoxylate-atropine + Yohimbine
Severity: Minor
Diphenoxylate-atropine and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects and could partly offset diphenoxylate sedation, but the clinical effect is not well established. Yohimbine can also cause tachycardia and hypertension, which anticholinergic atropine may add to.
What this interaction means in plain words
Diphenoxylate-atropine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects, with possible additive heart rate increases from alpha-2 blockade and muscarinic blockade; not well characterized.
What to do
Monitor heart rate, blood pressure and anxiety or agitation. No routine dose changes are needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Yohimbine?
MediHelp rates the interaction as minor. Diphenoxylate-atropine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects and could partly offset diphenoxylate sedation, but the clinical effect is not well established. Yohimbine can also cause tachycardia and hypertension, which anticholinergic atropine may add to.
How serious is the interaction between Diphenoxylate-atropine and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and anxiety or agitation. No routine dose changes are needed.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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