Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis vaccine + Ifosfamide
Severity: Moderate
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide-induced immunosuppression can reduce antibody responses to inactivated DTaP vaccine. Patients may remain unprotected despite vaccination.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs the immune response to vaccination.
What to do
Vaccinate at least 2 weeks before chemotherapy when feasible. Revaccinate about 3 months after chemotherapy ends if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis vaccine with Ifosfamide?
MediHelp rates the interaction as moderate. Diphtheria and tetanus toxoids / acellular pertussis vaccine and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide-induced immunosuppression can reduce antibody responses to inactivated DTaP vaccine. Patients may remain unprotected despite vaccination.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis vaccine and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before chemotherapy when feasible. Revaccinate about 3 months after chemotherapy ends if given during treatment.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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