Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis vaccine + Prednisolone
Severity: Minor
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a non-live combination vaccine and is safe to give, but immunosuppressive prednisolone doses may reduce the antibody response to its components. Protection may be somewhat lower.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Corticosteroid suppression of lymphocyte function modestly reduces vaccine-induced antibody production.
What to do
Vaccinate on schedule; do not delay. Consider assessing antibody levels or giving additional doses if given during prolonged high-dose therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis vaccine with Prednisolone?
MediHelp rates the interaction as minor. Diphtheria and tetanus toxoids / acellular pertussis vaccine and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. This is a non-live combination vaccine and is safe to give, but immunosuppressive prednisolone doses may reduce the antibody response to its components. Protection may be somewhat lower.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis vaccine and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate on schedule; do not delay. Consider assessing antibody levels or giving additional doses if given during prolonged high-dose therapy.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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