Drug interactions
Diphtheria and tetanus toxoids + Ifosfamide
Severity: Moderate
Diphtheria and tetanus toxoids and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide causes myelosuppression and immunosuppression, which can blunt the antibody response to toxoid vaccines. Protection may be inadequate if vaccinated during chemotherapy.
What this interaction means in plain words
Diphtheria and tetanus toxoids and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs the immune response to vaccination.
What to do
Vaccinate at least 2 weeks before starting chemotherapy where possible. If given during therapy, revaccinate about 3 months after chemotherapy once immune recovery has occurred.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids with Ifosfamide?
MediHelp rates the interaction as moderate. Diphtheria and tetanus toxoids and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide causes myelosuppression and immunosuppression, which can blunt the antibody response to toxoid vaccines. Protection may be inadequate if vaccinated during chemotherapy.
How serious is the interaction between Diphtheria and tetanus toxoids and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting chemotherapy where possible. If given during therapy, revaccinate about 3 months after chemotherapy once immune recovery has occurred.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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