Drug interactions
Diphtheria and tetanus toxoids + Tocilizumab
Severity: Minor
Diphtheria and tetanus toxoids and Tocilizumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
These toxoid vaccines are non-live and may be given with tocilizumab. The antibody response might be somewhat reduced.
What this interaction means in plain words
Diphtheria and tetanus toxoids and Tocilizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic: IL-6 receptor blockade may slightly attenuate antibody responses.
What to do
Give boosters as scheduled, including for wound management. No change in tocilizumab is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids with Tocilizumab?
MediHelp rates the interaction as minor. Diphtheria and tetanus toxoids and Tocilizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. These toxoid vaccines are non-live and may be given with tocilizumab. The antibody response might be somewhat reduced.
How serious is the interaction between Diphtheria and tetanus toxoids and Tocilizumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give boosters as scheduled, including for wound management. No change in tocilizumab is needed.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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