Drug interactions
Measles mumps rubella and varicella vaccine live + Tocilizumab
Severity: Contraindicated
Measles mumps rubella and varicella vaccine live and Tocilizumab: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This live combination vaccine may cause disseminated measles, mumps, rubella or varicella vaccine-strain disease in patients on tocilizumab. The immune response to the vaccine may also be diminished.
What this interaction means in plain words
Measles mumps rubella and varicella vaccine live and Tocilizumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
IL-6 receptor blockade impairs control of live attenuated virus replication.
What to do
Avoid during tocilizumab treatment. Give at least 4 weeks before starting therapy if feasible, or use separate non-live strategies as appropriate.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Measles mumps rubella and varicella vaccine live and Tocilizumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
- Tocilizumab + Typhoid vaccine live Contraindicated
Frequently asked questions
Can I take Measles mumps rubella and varicella vaccine live with Tocilizumab?
MediHelp rates the interaction as contraindicated. Measles mumps rubella and varicella vaccine live and Tocilizumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This live combination vaccine may cause disseminated measles, mumps, rubella or varicella vaccine-strain disease in patients on tocilizumab. The immune response to the vaccine may also be diminished.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Tocilizumab?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during tocilizumab treatment. Give at least 4 weeks before starting therapy if feasible, or use separate non-live strategies as appropriate.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles vaccine. The full list is on the Tocilizumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
