Drug interactions
Dipipanone + Doxylamine
Severity: Major
Dipipanone and Doxylamine: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is an opioid analgesic and doxylamine is a sedating antihistamine. Combined use can deepen sedation and slow breathing more than either drug alone. The risk is greatest in older adults and when doses are high.
What this interaction means in plain words
Dipipanone and Doxylamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1 antihistamine sedation.
What to do
Avoid combining where possible, or use the lowest effective doses and monitor sedation and respiratory rate. Advise against alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Doxylamine
Frequently asked questions
Can I take Dipipanone with Doxylamine?
MediHelp rates the interaction as major. Dipipanone and Doxylamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipipanone is an opioid analgesic and doxylamine is a sedating antihistamine. Combined use can deepen sedation and slow breathing more than either drug alone. The risk is greatest in older adults and when doses are high.
How serious is the interaction between Dipipanone and Doxylamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or use the lowest effective doses and monitor sedation and respiratory rate. Advise against alcohol and driving.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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