Drug interactions
Dipipanone + Imipramine
Severity: Moderate
Dipipanone and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is a strong opioid analgesic, and combining it with a sedating tricyclic such as imipramine increases CNS depression. This can cause marked drowsiness, impaired coordination and respiratory depression. Tricyclics may also increase opioid-related constipation through their anticholinergic effects.
What this interaction means in plain words
Dipipanone and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depressant effects, with additive anticholinergic effects.
What to do
Start with low doses and titrate cautiously, monitoring sedation and respiratory rate. Counsel the patient about driving and about avoiding alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Dipipanone with Imipramine?
MediHelp rates the interaction as moderate. Dipipanone and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipipanone is a strong opioid analgesic, and combining it with a sedating tricyclic such as imipramine increases CNS depression. This can cause marked drowsiness, impaired coordination and respiratory depression. Tricyclics may also increase opioid-related constipation through their anticholinergic effects.
How serious is the interaction between Dipipanone and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate cautiously, monitoring sedation and respiratory rate. Counsel the patient about driving and about avoiding alcohol and other sedatives.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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