Drug interactions
Dipipanone + Oxazepam
Severity: Major
Dipipanone and Oxazepam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is an opioid analgesic, and combining it with a benzodiazepine can cause profound sedation, respiratory depression, coma and death.
What this interaction means in plain words
Dipipanone and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via mu-opioid agonism and GABA-A potentiation.
What to do
Avoid unless no alternatives exist; then use the lowest doses for the shortest duration and monitor sedation and respiration closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Dipipanone with Oxazepam?
MediHelp rates the interaction as major. Dipipanone and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipipanone is an opioid analgesic, and combining it with a benzodiazepine can cause profound sedation, respiratory depression, coma and death.
How serious is the interaction between Dipipanone and Oxazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless no alternatives exist; then use the lowest doses for the shortest duration and monitor sedation and respiration closely.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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